Stroke mortality associated with environmental tobacco smoke among never-smoking Japanese women: a prospective cohort study.

Research paper by Yoshikazu Y Nishino, Ichiro I Tsuji, Hideo H Tanaka, Tomio T Nakayama, Haruo H Nakatsuka, Hidemi H Ito, Takaichiro T Suzuki, Kota K Katanoda, Tomotaka T Sobue, Suketami S Tominaga,

Indexed on: 02 Jul '14Published on: 02 Jul '14Published in: Preventive Medicine


This study examined the association of exposure to environmental tobacco smoke (ETS) during adulthood with stroke and its subtypes using data from a large-scale prospective cohort study in Japan.The study population included 36,021 never-smoking Japanese women who were enrolled between 1983 and 1985 and were followed-up for 15 years. We used Cox proportional hazard regression models to estimate hazard ratios (HRs) for stroke death associated with ETS exposure at home during adulthood.A total of 906 cases of stroke death were observed during 437,715 person-years of follow-up. Compared with never-smoking women without smoking family members, HRs for stroke mortality among never-smoking women living with smoking family members in all subjects, in those aged 40-79 years, and in those aged ≥ 80 years were 1.14 (95% confidence interval: 0.99-1.31), 1.24 (95% CI: 1.05-1.46), and 0.89 (95% CI: 0.66-1.19), respectively, after adjustment for possible confounders. The risk was most evident for subarachnoid hemorrhage [HR: 1.66 (95% CI: 1.02-2.70) in all subjects].This study suggests that exposure to ETS at home during adulthood is associated with an increased risk of stroke among never-smoking Japanese women.