Quantcast

Stereoselective construction of Bi-spirooxindole frameworks via a Michael addition/cyclization and an unexpected redox/oxidative coupling/cyclization

Research paper by Xiao-Qian Zhu, Jia-Shou Wu, Jian-Wu Xie

Indexed on: 09 Nov '16Published on: 03 Nov '16Published in: Tetrahedron



Abstract

A series of polyheterocyclic bi-spirooxindole derivatives with skeletal diversity and molecular complexity were prepared via a cascade synthesis strategy. The key step transfer hydrogenation is smoothly fulfilled by using 3-hydroxyoxindole derivatives as the hydrogen source and the oxidative coupling happened by using simple and green molecular oxygen as the oxidant. The plausible mechanisms for the unexpected redox/oxidative coupling/cyclization were also given.

Graphical abstract 10.1016/j.tet.2016.11.001.jpg
Figure 10.1016/j.tet.2016.11.001.0.jpg
Figure 10.1016/j.tet.2016.11.001.1.jpg