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Stereocontrolled synthesis of the sterically encumbered F ring of lancifodilactone G.

Research paper by Kwong Wah KW Lai, Leo A LA Paquette

Indexed on: 06 May '08Published on: 06 May '08Published in: Organic Letters



Abstract

A stereochemically linear strategy has been developed to prepare the heavily congested F-ring sector of lancifodilactone G (1) from commercially inexpensive (R)-carvone. Prominent operations in our synthesis include Negishi-type sp2-sp3 cross-coupling and intramolecular free-radical cyclization for the purpose of appending the sidearm links of the D and H rings onto the F platform.