Stem Cells and combination therapy for the Treatment of Traumatic Brain Injury.

Imported: 04 Jan '17 | Published: 04 Jan '17

AmiraSan A Dekmak, Sarah S Mantash, Abdullah A Shaito, Amer A Toutonji, Naify N Ramadan, Hussein H Ghazale, Nouhad N Kassem, Hala H Darwish, Kazem K Zibara

Behavioural Brain Research

Abstract: TBI is a nondegenerative, noncongenital insult to the brain from an external mechanical force; for instance a violent blow in a car accident. It is a complex injury with a broad spectrum of symptoms and has become a major cause of death and disability in addition to being a burden on public health and societies worldwide. As such, finding a therapy for TBI has become a major health concern for many countries, which has led to the emergence of many monotherapies that have shown promising effects in animal models of TBI, but have not yet proven any significant efficacy in clinical trials. In this paper, we will review existing and novel TBI treatment options. We will first shed light on the complex pathophysiology and molecular mechanisms of this disorder, understanding of which is a necessity for launching any treatment option. We will then... Read More

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