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Stabilization of the Pro-Tyr-Gly-NH2 melanostatin analog on micelles

Research paper by Yu. E. Shapiro, V. Ya. Gorbatyuk, A. A. Mazurov, S. A. Andronati

Indexed on: 01 Jan '94Published on: 01 Jan '94Published in: Theoretical and Experimental Chemistry



Abstract

Inversed AOT micelles have been used as a system to simulate peptide-receptor interaction; they encapsulate an aqueous solution of the melanostatin analog HCl·Pro-Tyr-Gy-NH2. NOESY indicates that adsorption at the phase boundary causes the peptide to acquire the biologically active βII conformation. The phenyl ring in Tyr is inserted into the cavity formed by the isooctyl moieties of the AOT molecules.