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Spectroscopic studies of the interaction between quercetin and G-quadruplex DNA.

Research paper by Hongxia H Sun, Yalin Y Tang, Junfeng J Xiang, Guangzhi G Xu, Yazhou Y Zhang, Hong H Zhang, Lianghua L Xu

Indexed on: 20 Apr '06Published on: 20 Apr '06Published in: Bioorganic & Medicinal Chemistry Letters



Abstract

Quercetin is a kind of flavonoid which has been proved to exhibit anti-tumor activity. The interaction modes of quercetins with monomeric and dimeric G-quadruplexes were studied by absorption, fluorescence, CD, and (1)H NMR spectroscopies. The ligands were found to be stacked with terminal tetrads of monomeric G-quadruplexes by intercalation and bound to dimeric G-quadruplexes by groove binding.