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SOCS proteins and caveolin-1 as negative regulators of endocrine signaling.

Research paper by Jean-François JF Jasmin, Isabelle I Mercier, Federica F Sotgia, Michael P MP Lisanti

Indexed on: 18 Apr '06Published on: 18 Apr '06Published in: Trends in Endocrinology and Metabolism



Abstract

Recently, a new class of regulatory molecules has emerged; these molecules, termed SOCS proteins, function as suppressors of cytokine signaling. SOCS proteins negatively regulate the Janus kinase signal transducer and activator of transcription (JAK-STAT) signaling cascade. Interestingly, it appears that other proteins, such as caveolin-1, can also function as suppressors of cytokine signaling by inhibiting the kinase activity of JAK family members. This might result from the ability of caveolin-1 to function as a broad-spectrum kinase inhibitor through the caveolin-scaffolding domain.