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Social jetlag and metabolic control in non-communicable chronic diseases: a study addressing different obesity statuses.

Research paper by Maria Carliana MC Mota, Catarina Mendes CM Silva, Laura Cristina Tibiletti LCT Balieiro, Walid Makin WM Fahmy, Cibele Aparecida CA Crispim

Indexed on: 27 Jul '17Published on: 27 Jul '17Published in: Scientific Reports



Abstract

Social jetlag - a measure of disruption of the circadian system - has been linked to obesity, but its association with metabolic complications in non-communicable chronic diseases (NCCDs) is unknown in the literature. We examined the associations between social jetlag and obesity status and metabolic parameters among individuals with NCCDs. Patients (n = 792) with NCCDs (obesity, systemic arterial hypertension, type 2 diabetes mellitus or dyslipidaemia) attended clinics of the public health service of the city of Uberlândia, Minas Gerais State, Brazil. They were classified in three obesity statuses: non-obese: BMI < 30 kg/m(2); metabolically healthy obese (MHO): BMI ≥ 30 kg/m(2) and less than three high-risk biomarkers for metabolic syndrome; and metabolically unhealthy obese (MUO): BMI ≥ 30 kg/m(2) and with high-risk values on three or more biomarkers for metabolic syndrome. After adjustments for confounding variables, social jetlag was positively associated with fasting glucose levels among all subjects (β = 0.08, p = 0.03) and MUO subjects (β = 0.32, p < 0.001). Patients with social jetlag (>1 h) presented a significant odds ratio (OR) of being overweight (OR = 2.0, confidence interval (CI) = 1.2-3.6, p = 0.006) and MUO (OR = 1.8, CI = 1.1-2.8, p = 0.01). These results suggest that social jetlag is associated with a higher risk of overweight and related metabolic complications in individuals with NCCDs.