Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice.

Research paper by Nan N Wu, Kang K Ho Kim, Ying Y Zhou, Jae J Man Lee, Nicole M NM Kettner, Jennifer L JL Mamrosh, Sungwoo S Choi, Loning L Fu, David D DD Moore

Indexed on: 19 Jul '16Published on: 19 Jul '16Published in: Molecular endocrinology (Baltimore, Md.)


Circadian rhythm regulates multiple metabolic processes, and in turn is readily entrained by feeding-fasting cycles. However, the molecular mechanisms by which the peripheral clock senses nutrition availability remain largely unknown. Bile acids are under circadian control and also increase postprandially, serving as regulators of the fed state in the liver. Here we show that nuclear receptor SHP, a regulator of bile acid metabolism, impacts the endogenous peripheral clock by directly regulating Bmal1. Bmal1-dependent gene expression is altered in Shp knockout (KO) mice, and liver clock adaptation is delayed in Shp KO mice upon restricted feeding.These results identify SHP as a potential mediator connecting nutrient signaling with the circadian clock.