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Silver-Mediated Perfluoroalkylation of Terminal Alkynes with Perfluoroalkyl Iodides.

Research paper by Junlan J Li, Lihua L Liu, Kaiting K Zheng, Chenggong C Zheng, Hua H Xiao, Shilu S Fan

Indexed on: 09 Jun '20Published on: 09 Jun '20Published in: Journal of Organic Chemistry



Abstract

The incorporation of perfluoroalkyl group (RF) into drug candidate has become an increasingly important strategy in the drug molecule design. In this study, the silver-mediated perfluoroalkylation reaction based on the addition-elimination process of terminal alkynes which was initiated by perfluoroalkyl radical to form C(sp)-RF bond has been developed. The reaction proceeds under mild conditions using readily available, low-cost perfluoroalkyl iodides as the sources of the RF group. This method allows access to a variety of perfluoroalkylated alkynes.