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Silencing TRPC1 expression inhibits invasion of CNE2 nasopharyngeal tumor cells.

Research paper by Benfu B He, Feiye F Liu, Jian J Ruan, Aimin A Li, Jinzhang J Chen, Rong R Li, Jie J Shen, Dayong D Zheng, Rongcheng R Luo

Indexed on: 01 Mar '12Published on: 01 Mar '12Published in: Oncology reports



Abstract

The invasion and metastasis processes involved in nasopharyngeal carcinoma (NPC) remain enigmatic. Transient receptor potential channel-related protein 1 (TRPC1) is a cation channel involved in diverse cellular functions by precisely controlling Ca2+. The role of this unique TRPC member in nasopharyngeal malignancies has not yet been delineated. Here, we downregulated TRPC1 in CNE2 cells by RNAi technology and by using 2-APB, an inhibitor of the inositol 1,4,5-trisphosphate (IP3) receptor and of store-operated Ca2+ channel-mediated Ca2+ entry. Both types of TRPC1 inhibition resulted in significantly attenuated adhesive and invasive abilities, suggesting that TRPC1 can modulate the metastasis of NPC. These findings support further investigation of the potential of TRPC1 as a novel therapeutic target for intervention in nasopharyngeal carcinoma.