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Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy among cognitively normal older people.

Research paper by Shanshan S Shen, Wenjun W Zhou, Xujiao X Chen, Jie J Zhang,

Indexed on: 20 May '19Published on: 19 May '19Published in: European Journal of Neurology



Abstract

To determine the effects of Apolipoprotein E ε4 (APOE ε4) genotype and sex together on longitudinal change in adjusted hippocampal volume (hippocampal volume/intracranial volume ratio [HpVR]) across the Alzheimer's disease (AD) continuum. At baseline, we included 372 individuals with normal cognition (NC), 738 individuals with mild cognitive impairment (MCI), and 271 patients with mild AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database. We examined the effects of the APOE ε4 by sex interaction on longitudinal change in HpVR within the overall sample and within each diagnostic group. Female gender was found to be associated with longitudinal reduction of HpVR in the NC and MCI groups, but not the AD group. Similarly, APOE ε4 was associated with longitudinal reduction of HpVR in the NC and MCI groups, but not the AD group. Further, female APOE ε4 carriers showed a greater longitudinal reduction of HpVR than their male counterparts in the NC group, but not the MCI or AD group. However, due to the relatively short duration of follow-up visits among AD patients, further studies are needed to replicate these findings. Female APOE ε4 carriers show a greater longitudinal reduction of HpVR than their male counterparts in cognitively normal older adults. This article is protected by copyright. All rights reserved.