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Sex differences in the association between apolipoprotein E ε4 allele and Alzheimer's disease markers.

Research paper by Erin E EE Sundermann, My M Tran, Pauline M PM Maki, Mark W MW Bondi

Indexed on: 06 Sep '18Published on: 06 Sep '18Published in: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring



Abstract

We determined whether the effect of apolipoprotein E ()-ε4 genotype on Alzheimer's disease (AD) markers differs in men and women across AD stages. Among normal control (NC) participants (N = 702) and participants with mild cognitive impairment (N = 576) and AD (N = 305), we examined the associations of sex and -ε4 carrier status with cortical amyloid-β (Aβ) burden, hippocampal volume ratio (HpVR; hippocampal volume/intracranial volume × 10), brain glucose metabolism, and verbal memory. In NC, -ε4 related to greater Aβ burden and poorer verbal memory across sex but to smaller HpVR and hypometabolism in men only. In mild cognitive impairment, -ε4 related to smaller HpVR, hypometabolism, greater Aβ burden, and poorer verbal memory across sex. In AD, -ε4 related to greater Aβ burden in men only and smaller HpVR across sex and showed no association with hypometabolism or verbal memory. Sex differences in the association between -ε4 and AD markers vary by disease stage.