Severe hypersomnolence associated with periodic limb movements and central sleep apnea in a cocaine addicted HIV patient.

Research paper by Raghunandan Dudda RD Subramanya, Siva S Ramachandran

Indexed on: 07 Feb '06Published on: 07 Feb '06Published in: Sleep Medicine

Abstract

Drugs such as cocaine and amphetamines potentiate the effect of epinephrine and norepinephrine on the brain and act as stimulants. Here, we report a case of paradoxical severe hypersomnolence from cocaine use in an HIV cocaine-addicted patient. We describe a possible pathomechanism for cocaine depletion at the synapse, causing decreased synaptic activation and leading to sleepiness.

Severe hypersomnolence associated with periodic limb movements and central sleep apnea in a cocaine addicted HIV patient.

Abstract

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Severe hypersomnolence associated with periodic limb movements and central sleep apnea in a cocaine addicted HIV patient.

Abstract

More like this:

Extended access of cocaine self-administration results in tolerance to the dopamine-elevating and locomotor-stimulating effects of cocaine.

Phenytoin toxicity from cocaine adulteration.

Orexin-1 receptor signaling increases motivation for cocaine-associated cues.

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