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Serum amyloid A in equine health and disease.

Research paper by O D OD Witkowska-Piłaszewicz, M M Żmigrodzka, A A Winnicka, A A Miśkiewicz, K K Strzelec, A A Cywińska

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Equine Veterinary Journal



Abstract

Serum amyloid A (SAA) is the major acute phase protein in horses. It is produced during the acute phase response (APR), a non-specific systemic reaction to any type of tissue injury. In the blood of healthy horses, SAA concentration is very low, but it increases dramatically with inflammation. Due to the short half-life of SAA, changes in its concentration in blood closely reflect the onset of inflammation and therefore, measurement of SAA useful in the diagnosis and monitoring of disease and response to treatment. Increases in SAA concentration have been described in equine digestive, reproductive and respiratory diseases and following surgical procedures. Moreover, SAA has proven useful for detection of some subclinical pathologies that can disturb training and competing in equine athletes. Increasing availability of diagnostic tests for both laboratory and field use, adds to SAA's applicability as a reliable indicator of horses' health status. This review article presents the current information on changes of SAA concentrations in the blood of healthy and diseased horses, focussing on clinical application of this biomarker. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.