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Sendai virus F glycoprotein induces IL-6 production in dendritic cells in a fusion-independent manner.

Research paper by Hayato H Suzuki, Masayuki M Kurooka, Yoko Y Hiroaki, Yoshinori Y Fujiyoshi, Yasufumi Y Kaneda

Indexed on: 25 Mar '08Published on: 25 Mar '08Published in: FEBS Letters



Abstract

We previously reported that inactivated Sendai virus particle (hemagglutinating virus of Japan envelope; HVJ-E) has anti-tumor effects by eliciting IL-6 production in dendritic cells (DCs). In the present study, we investigated which components of HVJ-E elicit IL-6 production. HVJ-E containing F0 protein inactive for virus envelope-cell membrane fusion enhanced IL-6 production. Reconstituted liposomes containing F protein stimulated IL-6 production. The antibody against F protein inhibited IL-6 secretion by HVJ-E. When carbohydrate chains of the F glycoprotein were removed, HVJ-E lost the ability to stimulate IL-6 secretion. These results suggest that F glycoprotein is required for IL-6 production in DCs.