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Semi-interpenetrating polymer networks composed of silk fibroin and poly(ethylene glycol) for wound dressing.

Research paper by Haeyong H Kweon, Joo-hong JH Yeo, Kwang-gill KG Lee, Hyun Chul HC Lee, Hee Sam HS Na, Young Ho YH Won, Chong Su CS Cho

Indexed on: 19 Aug '08Published on: 19 Aug '08Published in: Biomedical materials (Bristol, England)



Abstract

Semi-interpenetrating polymer networks (SIPNs) composed of silk fibroin (SF) and poly(ethylene glycol) (PEG) were prepared by photopolymerization of a PEG macromer in the presence of SF to improve the mechanical properties of SF sponge as wound dressing. The morphological structure of the SF/PEG SIPNs was observed to be composed of an interconnected microporous surface and a cross-sectional area. SF/PEG SIPNs showed non-cytotoxicity evaluated by a cell proliferation method using L929 fibroblasts. Wound contraction treated with SF/PEG SIPNs sponges was faster than that of Vaseline gauze as a control. Histological observation confirmed that the deposition of collagen in the dermis was organized by covering the wound area with SF/PEG SIPNs. The above results indicated that SF/PEG SIPNs could be used as wound dressing.