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Rosmarinic Acid Attenuates Cell Damage against UVB Radiation-Induced Oxidative Stress via Enhancing Antioxidant Effects in Human HaCaT Cells.

Research paper by Pattage Madushan Dilhara Jayatissa PM Fernando, Mei Jing MJ Piao, Kyoung Ah KA Kang, Yea Seong YS Ryu, Susara Ruwan Kumara Madduma SR Hewage, Sung Wook SW Chae, Jin Won JW Hyun

Indexed on: 14 Jan '16Published on: 14 Jan '16Published in: Biomolecules & therapeutics



Abstract

This study was designed to investigate the cytoprotective effect of rosmarinic acid (RA) on ultraviolet B (UVB)-induced oxidative stress in HaCaT keratinocytes. RA exerted a significant cytoprotective effect by scavenging intracellular ROS induced by UVB. RA also attenuated UVB-induced oxidative macromolecular damage, including protein carbonyl content, DNA strand breaks, and the level of 8-isoprostane. Furthermore, RA increased the expression and activity of superoxide dismutase, catalase, heme oxygenase-1, and their transcription factor Nrf2, which are decreased by UVB radiation. Collectively, these data indicate that RA can provide substantial cytoprotection against the adverse effects of UVB radiation by modulating cellular antioxidant systems, and has potential to be developed as a medical agent for ROS-induced skin diseases.