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Resistance of recentNeisseria gonorrhoeae isolates in nigeria and outcome of single-dose treatment with ciprofloxacin

Research paper by J. A. M. Otubu, G. E. Imade, A. S. Sagay, O. A. Towobola, M. Phil

Indexed on: 01 Nov '92Published on: 01 Nov '92Published in: Infection



Abstract

One hundred four patients (71 males, 33 females) with acute gonococcal urethritis or cervicitis were treated with a single oral 250 mg dose of ciprofloxacin at Jos University Teaching Hospital, Jos, Nigeria. All gonococcal strains were isolated from appropriate pre-treatment swabs. Penicillinase-producingNeisseria gonorrhoeae (PPNG) accounted for 72.8% of all isolates.In vitro sensitivity of gonococcal isolates to ciprofloxacin was 100%, while that to penicillin, ampicillin and co-trimoxazole was below 15%. Of the 104 patients treated with ciprofloxacin, 73 (70%) attended a follow-up visit. Seventy-three (100%) patients showed clinical cure and elimination ofN. gonorrhoeae from the respective site of infection. Post-gonococcal urethritis or cervicitis believed to be due to concomitant chlamydial infection was found in 22 (30.1%) patients — 18 males and four females. No adverse reactions were reported by any patient. Our findings show that a single oral dose of ciprofloxacin (250 mg) is well tolerated and effective in the treatment of uncomplicated gonorrhoea and is particularly useful in regions with a high prevalence of PPNG.