Residues of salbutamol and identification of its metabolites in beef cattle.

Research paper by Kai K Zhang, Chaohua C Tang, Qingshi Q Meng, Wei W Du, Tao T Bo, Qingyu Q Zhao, Xiaowei X Liang, Shengsheng S Liu, Zhixu Z Zhang, Junmin J Zhang

Indexed on: 23 Mar '17Published on: 23 Mar '17Published in: Journal of Agricultural and Food Chemistry


Salbutamol, a selective β2-agonist, endangers the safety of animal products because of illegal use in food animals. Residues of salbutamol and its metabolites were investigated to select appropriate targets and marker residues for monitoring the illegal use of salbutamol. Ten metabolites of salbutamol were identified from plasma, urine, liver, and kidney samples; of these, six were newly identified. There were significant differences (P < 0.01) between the concentrations of parent (non-conjugated) and total (conjugated + non-conjugated) salbutamol in plasma, urine, liver, and kidney tissues. Salbutamol residues in urine were relatively higher than in plasma and other internal tissues during the dosing period, and were rapidly eliminated from plasma, heart, spleen, and kidney tissues during withdrawal time. Total salbutamol was identified as more preferable than parent salbutamol as a marker residue, and urine and eye tissues are more suitable as targets for pre-slaughter and post-slaughter monitoring of the illegal use of salbutamol in beef cattle.