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Renal Transplant Register of Andalusia, 2010 Report: survival in relation to the factors used in recipient selection.

Research paper by M A MA Gentil, M A MA Pérez-Valdivia, A A Rodriguez-Benot, E E Sola, A A Osuna, M A MA Mazuecos, R R Bedoya, J J Borrego, P P Castro, M M Alonso

Indexed on: 26 Oct '10Published on: 26 Oct '10Published in: Transplantation Proceedings



Abstract

Kidney transplantation is the best therapeutic alternative for patients suffering from end-stage renal disease (ESRD). In recent years a significant advance has been made in Andalusia in graft and recipient survival as seen in our 2009 publication. In the current work we analyzed 2989 kidney transplantations performed between January 1, 2000 and December 31, 2009 based on data obtained from the Renal Transplant Registry of Andalusia. We studied the influence on graft and patient survival of factors, such as donor and recipient age, HLA matching, HLA immunization, and duration of previous renal replacement therapy. Patient survival was influenced by age at the time of transplantation and by donor age; the younger the donor, the more it was improved. Graft survival was determined by the donor age group, with no differences at each level according to the recipient age group. No significant differences were observed in patient survival or graft or death-censored graft survival according to HLA matching. Patient and graft survivals were significantly affected by the duration of the previous renal replacement therapy. Despite this being a preliminary study, we have shown the importance of nonmodifiable factors in transplant survival, such as donor and recipient age, with HLA matching having a limited effect. These latter findings should be confirmed in the future by multivariate analyses.