Remote Oxidative C–H Amidation of Anilides with Dibenzenesulfonimides under Metal-Free Conditions

Research paper by Xiang, Dehu, Xia, Lan, Zhang, Yunhua, Zhang, Qian, Li, Dong

Indexed on: 29 May '18Published on: 06 May '18Published in: Synlett : accounts and rapid communications in synthetic organic chemistry


A remote oxidative C–H bond amidation of anilides with dibenzenesulfonimides mediated by PhI(OAc)2 under metal-free conditions provided para-amidated anilides with high selectivity and moderate to good yields. The reaction proceeded under mild or neutral conditions and it has good air and moisture tolerance. The method represents a novel and facile strategy for the synthesis of arylamines.