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Redox-responsive molecular nanoreservoirs for controlled intracellular anticancer drug delivery based on magnetic nanoparticles.

Research paper by Zhong Z Luo, Kaiyong K Cai, Yan Y Hu, Jinghua J Li, Xingwei X Ding, Beilu B Zhang, Dawei D Xu, Weihu W Yang, Peng P Liu

Indexed on: 20 Dec '11Published on: 20 Dec '11Published in: Advanced Materials



Abstract

A novel redox responsive controlled drug release system based on magnetic nanoparticles for efficient intracellular anticancer drug delivery is fabricated. Disulfide bonds are employed as intermediate linkers to immobilize PEI/β-CD molecules as nanoreservoirs for drug loading onto magnetic nanoparticles. The endocytotic pathway and endosomal escape of the smart controlled drug release system is proposed.