Rapid synthesis of radioiodinated ω-iodofatty acids

Research paper by G. W. Kabalka, E. E. Gooch, Ch. Otto

Indexed on: 01 Mar '81Published on: 01 Mar '81Published in: Journal of Radioanalytical and Nuclear Chemistry


A series of idine-125 labeled ω-iodofatty acids were synthesized via a recently developed hydroboration-iodination sequence. The sequence involves the hydroboration of appropriate alkenoic acids with dialkylboranes followed by the reaction of the resultant organoborane with iodine-125 monochloride. The ω-iodofatty acids contained 11, 16, 19 and 22 carbons respectively. Isolated radiochemical yields were in the 85–95% range.