Ramping up degradation for proliferation.

Research paper by Jon M JM Huibregtse, Andreas A Matouschek

Indexed on: 29 Jan '16Published on: 29 Jan '16Published in: Nature Cell Biology


The control of proteasome-mediated protein degradation is thought to occur mainly at the level of polyubiquitylation of the substrate. However, the proteasome can also be regulated directly, as now demonstrated by a study in which DYRK2-mediated phosphorylation of the 19S subunit Rpt3 is found to increase proteasome activity.