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Radioimmunologische Methode zur Aldosteronbestimmung im Urin

Research paper by A. Helber, W. Kaufmann

Indexed on: 01 Dec '73Published on: 01 Dec '73Published in: Klinische Wochenschrift



Abstract

The principles of a radioimmunological method for determination of aldosterone in urine, its reliability, reproducibility and accuracy are reported. In 15 controls, the aldosterone excretion measured by this method corresponded to 7.5±3.7 µg/day with uncontrolled sodium intake. At comparable conditions, the aldosterone excretion of 12 patients with essential hypertension was 8.5±4.4 µg/day. Sodium deprivation over 4 days with a diet containing 45 mval sodium per day lead to a marked elevation of aldosterone excretion which was however very different from patient to patient. Sodium loading with 260 mval sodium per day was able to suppress aldosterone excretion to subnormal values in 8 out of 10 patients.