Quantcast

Protein evolution: when two become three.

Research paper by Pierre P Stallforth, Jon J Clardy

Indexed on: 15 Sep '12Published on: 15 Sep '12Published in: Current Biology



Abstract

Bacterial signaling pathways provide wonderful systems for analyzing protein evolution in vivo. A systematic dissection of the phosphate-sensing machinery in proteobacteria shows that adaptive, not neutral, mutations disable deleterious crosstalk with closely related signaling systems.