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Proanthocyanidin Metabolism, a mini review

Research paper by Y.Y. Choy, Viticulture and Enology, University of California, Davis, CA, USA<br>A.L. Waterhouse, Viticulture and Enology, University of California, Davis, CA, USA

Indexed on: 14 May '16Published on: 12 Jun '14Published in: Nutrition and aging (Amsterdam, Netherlands)



Abstract

There is emerging evidence suggesting that consumption of beverage and food rich in polyphenol may offer protective effects against various neurodegenerative, cardiovascular diseases and cancers. Proanthocyanidins (PACs) are one of the most abundant polyphenol in human diets, but also one of the least absorbed polyphenol mostly due to their size and structure complexity. PACs or condensed tannins are oligomers and polymers of monomeric unit flavan-3-ol (+)-catechin or (−)-epicatechin. To date, the absorption and metabolism of PACs are still remains largely unknown. The aim of this mini review was to highlight the absorption and metabolism of PACs, their effect in the gut and sample preparation for analysis. Ultimately, the potential bioactivities derived from the interaction between PACs metabolites and the gut microbiota warrants further investigation. Content Type Journal ArticlePages 111-116DOI 10.3233/NUA-140038Authors Y.Y. Choy, Viticulture and Enology, University of California, Davis, CA, USAA.L. Waterhouse, Viticulture and Enology, University of California, Davis, CA, USA Journal Nutrition and AgingOnline ISSN 1879-7725Print ISSN 1879-7717 Journal Volume Volume 2 Journal Issue Volume 2, Number 2-3 / 2014 There is emerging evidence suggesting that consumption of beverage and food rich in polyphenol may offer protective effects against various neurodegenerative, cardiovascular diseases and cancers. Proanthocyanidins (PACs) are one of the most abundant polyphenol in human diets, but also one of the least absorbed polyphenol mostly due to their size and structure complexity. PACs or condensed tannins are oligomers and polymers of monomeric unit flavan-3-ol (+)-catechin or (−)-epicatechin. To date, the absorption and metabolism of PACs are still remains largely unknown. The aim of this mini review was to highlight the absorption and metabolism of PACs, their effect in the gut and sample preparation for analysis. Ultimately, the potential bioactivities derived from the interaction between PACs metabolites and the gut microbiota warrants further investigation. Content Type Journal ArticlePages 111-116DOI 10.3233/NUA-140038Authors Y.Y. Choy, Viticulture and Enology, University of California, Davis, CA, USAA.L. Waterhouse, Viticulture and Enology, University of California, Davis, CA, USA Content Type Journal ArticleContent Type Journal ArticlePages 111-116DOI 10.3233/NUA-140038Authors Y.Y. Choy, Viticulture and Enology, University of California, Davis, CA, USAA.L. Waterhouse, Viticulture and Enology, University of California, Davis, CA, USA Authors Y.Y. Choy, Viticulture and Enology, University of California, Davis, CA, USAA.L. Waterhouse, Viticulture and Enology, University of California, Davis, CA, USA Y.Y. Choy, Viticulture and Enology, University of California, Davis, CA, USAA.L. Waterhouse, Viticulture and Enology, University of California, Davis, CA, USA Journal Nutrition and AgingOnline ISSN 1879-7725Print ISSN 1879-7717 Journal Volume Volume 2 Journal Issue Volume 2, Number 2-3 / 2014 Journal Nutrition and AgingOnline ISSN 1879-7725Print ISSN 1879-7717 Journal Nutrition and AgingJournal Nutrition and AgingNutrition and AgingOnline ISSN 1879-7725Online ISSN 1879-7725Print ISSN 1879-7717Print ISSN 1879-7717 Journal Volume Volume 2 Journal Volume Volume 2Journal Volume Volume 2 Journal Issue Volume 2, Number 2-3 / 2014 Journal Issue Volume 2, Number 2-3 / 2014Journal Issue Volume 2, Number 2-3 / 2014Volume 2, Number 2-3 / 2014