Presence of CSE1L protein in urine of patients with urinary bladder urothelial carcinomas.

Research paper by Cheng-Jeng CJ Tai, Ching-Fong CF Liao, Tzu-Cheng TC Su, Ko-Hung KH Shen, Chun-Chao CC Chang, Shu-Hui SH Lin, Chung-Min CM Yeh, Shing-Chuan SC Shen, Woan-Ruoh WR Lee, Jeng-Fong JF Chiou, Chih-Hung CH Lin, Ying-Chun YC Chen, Hsin-Yi HY Shih, Kun-Tu KT Yeh, Ming-Chung MC Jiang

Indexed on: 02 Jun '12Published on: 02 Jun '12Published in: The International journal of biological markers


The chromosome segregation 1-like (CSE1L) protein is highly expressed in most cancers and has been shown to be secreted by tumor cells. We studied the presence of CSE1L in the urine of patients with bladder urothelial carcinomas. The results of our immunohistochemical analysis showed a high expression of CSE1L in bladder cancer specimens, while the normal bladder specimens only showed a very faint staining in some cells. Immunoblotting showed that CSE1L was present in urine of patients with bladder cancer. Urinary CSE1L-positive cases were detected in 95% (57/60) of patients with bladder urothelial carcinomas or the atypical/suspicious cases with urothelial atypia. No CSE1L was detected in urine of healthy controls (p<0.01). Our results suggest that urinary CSE1L deserves further evaluation for the screening of bladder cancer.