Preparation and characterization of uniform drug particles: dehydrocholic acid.

Research paper by Amr Ali AA Mohamed, Egon E Matijević

Indexed on: 14 Dec '11Published on: 14 Dec '11Published in: Journal of Colloid and Interface Science


Two methods for the preparation of uniform dispersions of dehydrocholic acid of different morphologies are described. In the first case, the drug was dissolved in acetone and then re-precipitated by adding a non-solvent (either water or an aqueous stabilizer solution), which yielded rod-like particles. In the second procedure, spheres, consisting of small elongated subunits, were obtained by acidification of basic aqueous solutions of the drug. The resulting particles were characterized in terms of their structure and surface charge characteristics.