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Prenylterphenyllin and its dehydroxyl analogs, new cytotoxic substances from a marine-derived Fungus Aspergillus candidus IF10.

Research paper by Hong H Wei, Hirohiko H Inada, Asami A Hayashi, Kenichi K Higashimoto, Patamaporn P Pruksakorn, Sayo S Kamada, Masayoshi M Arai, Shunsuke S Ishida, Motomasa M Kobayashi

Indexed on: 06 Oct '07Published on: 06 Oct '07Published in: The Journal of Antibiotics



Abstract

Three novel cytotoxic substances named prenylterphenyllin (1), 4''-deoxyprenylterphenyllin (2), and 4''-deoxyisoterprenin (3) were isolated from a cultured marine-derived fungus of Aspergillus candidus IF10 together with 4''-deoxyterprenin (4). Their chemical structures were elucidated on the basis of 2D NMR analysis. These compounds 1 approximately 4 showed cytotoxic activity against human epidermoid carcinoma KB cells (KB3-1) with IC(50) of 8.5, 3.0, 2.5, and 4.5 microg/ml, respectively.