Prenatal findings in a monozygotic twin pregnancy with Costello syndrome.

Research paper by T T Van den Bosch, D D Van Schoubroeck, J P JP Fryns, G G Naulaers, A M AM Inion, K K Devriendt

Indexed on: 10 May '02Published on: 10 May '02Published in: Prenatal Diagnosis


This report describes the prenatal findings in monozygotic twins with Costello syndrome. At 16 weeks one twin had 9 mm of nuchal oedema: coarctation of the aorta was diagnosed after birth. At 22(5/7) weeks relative macrocephaly, mild pyelectasia and moderate polyhydramnios were noted in both twins. In the following 4 weeks the polyhydramnios increased significantly without visualisation of filling of the stomach. Between 27(5/7) and 30(2/7) weeks a total of 9 l amniotic fluid was drained and at 30(4/7) weeks prelabor premature rupture of membranes (PPROM) occurred followed by premature labor and delivery. The neonatal period was complicated by growth retardation, deglutition problems, hypotonia, cardiac and respiratory problems. Both twins died on Day 57 because of respiratory insufficiency.