Preliminary study on the role of the human IZUMO gene in oocyte-spermatozoa fusion failure.

Research paper by Viviana V Granados-Gonzalez, Isabelle I Aknin-Seifer, Renaud-Lauriam RL Touraine, Jacques J Chouteau, Jean-Philippe JP Wolf, Rachel R Levy

Indexed on: 18 Dec '07Published on: 18 Dec '07Published in: Fertility and Sterility®

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Abstract

We studied the IZUMO gene 9 coding exons sequence in four groups of patients including those with fertilization failure by conventional IVF. We observed in our populations two combinations of four polymorphisms that appeared to be preferentially linked (CGG-CG and TAA-TT) without any significant difference between different genotype repartitions.