Pregnancy-associated plasma protein-A and the vulnerable plaque.

Research paper by Camilla H B CH Jespersen, Kirstine R KR Vestergaard, Morten M Schou, Børge B Teisner, Jens P JP Goetze, Kasper K Iversen

Indexed on: 25 Oct '14Published on: 25 Oct '14Published in: Biomarkers in medicine


For more than a decade, pregnancy-associated plasma protein-A (PAPP-A) has been examined for its relation to acute coronary syndrome (ACS) and the vulnerable plaque. This review summarizes the current knowledge of plasma PAPP-A in relation to nonpregnant individuals focusing on patients with ACS, discusses its use as a possible biomarker for diagnosis and prognosis in ACS, briefly describes the challenges in different assay technologies and describes the effect of heparin administration on PAPP-A concentrations in plasma.