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Pre- and Post-Transplant Bacterial Infections in Liver Transplant Recipients.

Research paper by Madeleine R MR Heldman, Stephen S Ngo, Peter B PB Dorschner, Mia M Helfrich, Michael G MG Ison

Indexed on: 02 Jul '20Published on: 30 Jul '19Published in: Transplant Infectious Disease



Abstract

Early (< 1 month) bacterial infection after liver transplant is a major cause of morbidity and mortality among liver transplant recipients. We investigated the impact of pre-transplant bacterial infection on early post-transplant bacterial infection incidence and outcomes. A retrospective cohort study identified all patients who underwent liver transplantation between January 1, 2011 and December 31, 2012 at a single tertiary center in the United States. Infections occurring within the 30 days prior to transplant and within the 30 following transplant were identified. Information regarding pre-transplant morbidity and post-transplant outcomes were collected. One-hundred seventy-four patients were included in the study. Forty patients (23%) experienced a total of 50 pre-transplant infections. Fifty-two (30%) developed a total of 62 post-transplant infections. Patients with a pre-transplant infection were more likely to develop a post-transplant infection compared to patients without a pre-transplant infection (48% [19 of 40] vs. 25% [33 of 134], respectively, P = 0.006). Patients with a pre-transplant infection had a longer mean post-transplant length of stay compared to those without a pre-transplant infection (16.3 days vs. 10.4 days, respectively, P <0.001), but survival at 30 days was similar in both groups (95% [38 of 40] vs. 97% [130 of 134, respectively, P =0.56). Among liver transplant recipients, pre-transplant infection is an important risk factor for early post-transplant bacterial infections. Pre-transplant infection is associated with increased early morbidity but not mortality after transplant. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.

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