Polymeric supra-amphiphiles based on terminal group electrostatic interactions: fabrication of micelles with modifiable surfaces.

Research paper by Zhi Z Liu, Jing J Qiao, Ye Y Tian, Man M Wu, Zhongwei Z Niu, Yong Y Huang

Indexed on: 12 Jul '14Published on: 12 Jul '14Published in: Langmuir


On the basis of terminal group electrostatic interactions (TGEI), a supra-amphiphile is formed between a homopolymer of polylactic acid with carboxyl group at one end (PLA-COOH) and hepta-6-hydrazyl-β-cyclodextrin (HH-CD). The amphiphile can self-assemble into a micellar structure in aqueous solution. The outer surface of the micelle, which is composed of cyclodextrins, can be further modified via host-guest interactions. Considering the biocompatibility of the building blocks, the application of the micelles in a nanocarrier of anticancer drugs is further explored.