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Polydopamine nanoparticles modulating stimuli-responsive PNIPAM hydrogels with cell/tissue adhesiveness.

Research paper by Lu L Han, Yanning Y Zhang, Xiong X Lu, Kefeng K Wang, Zhenming Z Wang, Hongping H Zhang

Indexed on: 07 Oct '16Published on: 07 Oct '16Published in: ACS Applied Materials & Interfaces



Abstract

Stimuli-responsive hydrogels can respond to stimuli by phase transformation or volume change and exhibit specific functions. Near-infrared (NIR) responsive hydrogel is a type of stimuli-responsive hydrogel, which can be precisely controlled by altering the radiation intensity, exposure time of the light source, and irradiation sites. Here, polydopamine nanoparticles (PDA-NPs) were introduced into a poly (N-isopropylacrylamide) (PNIPAM) network to fabricate a PDA-NPs/PNIPAM hydrogel with NIR responsibility, self-healability, and cell/tissue adhesiveness. After incorporation of PDA-NPs into the hydrogel, the PDA-NPs/PNIPAM hydrogel showed phase transitions and volume changes in response to NIR. Thus, the hydrogel can achieve triple response effects, including pulsatile drug release, NIR-driven actuation and NIR-assisted healing. After coating PDA-NPs onto hydrogel surfaces, the hydrogel showed improved cell affinity, good tissue adhesiveness, and growth factor/protein immobilization ability because of reactive catechol groups on PDA-NPs. The tissue adhesion strength to porcine skin was as high as 90 KPa. In vivo full-skin defect experiments demonstrated that PDA-NPs coating on the hydrogel and an immobilized growth factor had a synergistic effect on accelerating wound healing. In summary, we combined thermo-sensitive PNIPAM and mussel-inspired PDA-NPs to form a NIR-responsive hydrogel, which may have potential applications for chemical and physical therapies.