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Photoinduced, Copper-Promoted Regio- and Stereoselective Decarboxylative Alkylation of α,β-Unsaturated Acids with Alkyl Iodides.

Research paper by Chao C Wang, Yingjie Y Lei, Mengzhun M Guo, Qinyu Q Shang, Hong H Liu, Zhaoqing Z Xu, Rui R Wang

Indexed on: 21 Nov '17Published on: 21 Nov '17Published in: Organic Letters



Abstract

The first example of UV light-induced, copper-catalyzed regio- and stereoselective decarboxylative coupling of α,β-unsaturated acids with alkyl iodides was reported. Under standard conditions, the 1°, 2°, and 3° alkyl iodides proceeded smoothly with the E-selective alkenes obtained in uniformly good yields and high stereoselectivities.