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Photodynamic therapy of experimental sarcoma M-1 with boronated chlorine as a photosensitizer.

Research paper by M A MA Kaplan, V A VA Ol'shevskaya, Yu S YS Osipchuk, R G RG Nikitina, V N VN Kalinin

Indexed on: 10 Jun '14Published on: 10 Jun '14Published in: Bulletin of Experimental Biology and Medicine



Abstract

Using rat model of experimental sarcoma M-1 we studied the efficacy of photodynamic therapy with boronated chlorine as a photosensitizer in doses of 1.25, 2.5, 5.0, and 10.0 mg/ kg body weight. Laser irradiation was performed at energy densities of 150, 300 J/cm(2) and power density of 0.25 and 0.42 W/cm(2). Treatment efficacy was evaluated by the percentage of animals with complete tumor regression, percentage of tumor recurrence and, in cases of its growth, by tumor growth coefficient. The efficacy of photodynamic therapy depended on the dose of boronated chlorine and parameters of the laser irradiation. Optimal conditions were the dose of 2.5 mg/kg at laser energy density of 300 J/cm(2) and power density of 0.42 W/cm(2) and a dose of 5.0 mg/kg at 150 J/cm(2) and 0.25 W/cm(2).