Phosphorylcholine-carbohydrate-protein conjugates efficiently induce hapten-specific antibodies which recognize both Streptococcus pneumoniae and Neisseria meningitidis: a potential multitarget vaccine against respiratory infections.

Research paper by Sylvie S Bay, Valérie V Huteau, Maria-Leticia ML Zarantonelli, René R Pires, Joël J Ughetto-Monfrin, Muhamed-Kheir MK Taha, Patrick P England, Pierre P Lafaye

Indexed on: 23 Jul '04Published on: 23 Jul '04Published in: Journal of Medicinal Chemistry


Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-D-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc-ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc-ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections.