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Personalized Medicine in Pediatrics: The Clinical Potential of Orodispersible Films

Research paper by J. Carolina Visser, Herman J. Woerdenbag, Lidwien M. Hanff, Henderik W. Frijlink

Indexed on: 06 Apr '16Published on: 04 Apr '16Published in: AAPS PharmSciTech



Abstract

Children frequently receive medicines that are designed for adults. The dose of commercially available products is adapted, mostly based on the child’s bodyweight, thereby neglecting differences in pharmacokinetic and pharmacodynamics parameters. If commercial products are unsuitable for administration to children or are unavailable, extemporaneous pharmacy preparations are a good alternative. For this particular population, orodispersible films (ODFs) can be a highly attractive dosage form for the oral administration of drugs. ODFs are relatively easy to prepare in a hospital setting, create dose flexibility, and may suit an individual approach, especially for patients having difficulties in swallowing tablets or being fluid restricted. In this article, various aspects related to pharmacy preparations, clinical application, and preparation of ODFs for pediatric patients are highlighted and discussed.