Peripheral Oxidative Stress Markers in Patients with Bipolar Disorder during Euthymia and Siblings.

Research paper by Amparo A Tatay-Manteiga, Vicent V Balanzá-Martínez, Giovana G Bristot, Rafael R Tabarés-Seisdedos, Flavio F Kapczinski, Omar O Cauli

Indexed on: 21 Mar '19Published on: 09 Mar '19Published in: Endocrine, metabolic & immune disorders drug targets


Oxidative stress is increased during the acute phases of bipolar disorder (BD). Our aim here was to analyze oxidative stress biomarkers in patients with BD during euthymia and their siblings. Cross-sectional study perfomed in euthymic patients with BD-I (n=48), unaffected siblings (n=23) and genetically unrelated healthy controls (n=21). Protein carbonyl content (PCC), total anti-oxidant capacity (TRAP), lipid peroxidation (TBARS) and uric acid were measured as biomarkers of oxidative stress in blood. The anti-oxidant capacity (TRAP) was lower (p<0.001) in patients with BD compared to their siblings and controls, whereas no differences were observed in PCC, TBARS or uric acid. In patients, the concentrations of TRAP and TBARS were positively associated with the dose of valproic acid (p<0.05 and p<0.001, respectively). The concentrations of these biomarkers were not significantly associated with any of socio-demographic and clinical variables. A selective reduction in anti-oxidant capacity is present in BD during euthymia state, whereas other markers of oxidative stress are unaltered during euthymia. Siblings did not show any alterations in oxidative stress biomarkers. Oxidative stress might represent a state-dependent marker in BD. The association between treatment with valproic acid and oxidative stress markers in euthymia deserves further studies. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

More like this: