Pericardial effusion as a complication of chronic graft versus host disease.

Research paper by Keaton K Nasser, Kshipra K Joshi, Ella E Starobinska

Indexed on: 21 Dec '18Published on: 21 Dec '18Published in: BMJ case reports


A 24-year-old man with previous matched unrelated donor allogenic bone marrow transplant for aplastic anaemia and chronic graft versus host disease on steroid taper presented with progressively worsening anasarca. CT revealed large pericardial effusion, while echocardiogram was concerning for early tamponade physiology. He underwent emergent pericardiocentesis with pericardial drain placement. Extensive rheumatological and infectious work-up was unrevealing with patient's presentation attributed to pericardial graft versus host disease. This highlights the need of physicians to be aware of pericardial serositis as a complication of graft versus host disease due to its life-threatening complications, which require immediate intervention. © BMJ Publishing Group Limited 2018. No commercial re-use. See rights and permissions. Published by BMJ.