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Performing the synthesis of a complex molecule on sequentially linked columns: toward the development of a "synthesis machine".

Research paper by Stefan S France, Daniel D Bernstein, Anthony A Weatherwax, Thomas T Lectka

Indexed on: 01 Jul '05Published on: 01 Jul '05Published in: Organic Letters



Abstract

[reaction: see text] We describe the diastereoselective synthesis of a pharmaceutically active drug candidate via a column-based system. This methodology is complementary to classical solid-phase synthesis; individual columns are packed with resin-bound reagents and then linked in sequence and/or in parallel. In contrast to the traditional solid-phase approach, substrates are introduced in the mobile phase where they build up chemical complexity by percolating through the linked columns, ultimately eluting as the desired product.