Pemphigus vulgaris: bilateral plica semilunaris involvement.

Research paper by Jay M JM Fiore, Henry D HD Perry, Eric D ED Donnenfeld, Samuel A SA Berger

Indexed on: 04 Nov '10Published on: 04 Nov '10Published in: Cornea


To present a case of pemphigus vulgaris, involving the conjunctiva, specifically the plica semilunaris, in both eyes of a 33-year-old woman.Ocular evaluation showed bilateral plica semilunaris vegetations extending for 3 mm linearly. Sequential excisional biopsies of both affected plica were performed and sent for pathological examination and immunofluorescent staining.After each excisional biopsy, the patient's ocular symptoms resolved. Excisional biopsies showed suprabasilar clefting within the epithelium; lymphoplasmacytic infiltration and immunopathology showed intraepithelial intercellular and basement membrane zone staining with immunoglobulin G consistent with pemphigus vulgaris. At 1-year follow-up, the patient continues to be asymptomatic with no signs of recurrence.Excisional biopsy, in a very symptomatic patient with pemphigus vulgaris with conjunctival vegetations, may hasten his or her recovery.