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Pd-Catalyzed para-selective C-H difluoromethylation of aromatic carbonyls.

Research paper by Yang-Jie YJ Mao, Bing-Xin BX Wang, Qiu-Zi QZ Wu, Kun K Zhou, Shao-Jie SJ Lou, Dan-Qian DQ Xu

Indexed on: 20 Dec '18Published on: 20 Dec '18Published in: Chemical Communications



Abstract

A novel palladium catalyzed highly para-selective C-H difluoromethylation of electron-deficient aromatic carbonyls was developed. Diverse substituted aromatic ketones and benzoates were selectively difluoromethylated at the remote para-site of carbonyl groups in moderate to good yields. Moreover, the difuoromethylation was also compatible with several complex bioactive molecules.