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Patient-derived xenografts: A platform for accelerating translational research in prostate cancer.

Research paper by Alastair H AH Davies, Yuzhuo Y Wang, Amina A Zoubeidi

Indexed on: 21 Mar '17Published on: 21 Mar '17Published in: Molecular and Cellular Endocrinology



Abstract

Recently, there has been renewed interest in the development and characterization of patient-derived tumour xenograft (PDX) models. Numerous PDX models have been established for prostate cancer and, importantly, retain the principal molecular, genetic, and histological characteristics of the donor tumour. As such, these models provide significant improvements over standard cell line xenograft models for biological studies, preclinical drug development, and personalized medicine strategies. This review summarizes the current state of the art in this field, illustrating the opportunities and limitations of PDX models in translational prostate cancer research.