Palladium-catalyzed Heck-type cross-couplings of unactivated alkyl iodides.

Research paper by Caitlin M CM McMahon, Erik J EJ Alexanian

Indexed on: 24 Apr '14Published on: 24 Apr '14Published in: Angewandte Chemie International Edition


A palladium-catalyzed, intermolecular Heck-type coupling of alkyl iodides and alkenes is described. This process is successful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, including those with hydrogen atoms in the β position. The mild catalytic conditions enable intermolecular C-C bond formations with a diverse set of alkyl iodides and alkenes, including substrates containing base- or nucleophile-sensitive functionality.