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Overexpression of 14-3-3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma.

Research paper by Bor-Sheng BS Ko, Tzu-Ching TC Chang, Chiun C Hsu, Yao-Chang YC Chen, Tang-Long TL Shen, Shyh-Chang SC Chen, John J Wang, Kenneth K KK Wu, Yee-Jee YJ Jan, Jun-Yang JY Liou

Indexed on: 16 Mar '11Published on: 16 Mar '11Published in: Histopathology



Abstract

The results of our earlier studies suggested that 14-3-3ε is involved in cancer cell survival and growth. However, it is not clear whether 14-3-3ε plays a role in tumour metastasis and patient outcome. The aim of this study was to determine whether 14-3-3ε is a marker for predicting hepatocellular carcinoma (HCC) metastasis and survival.One hundred and fourteen patients with tissue-diagnosed primary HCC were followed for an average of 58.6 months. 14-3-3ε in liver tissues was analysed by immunohistochemistry, and quantified by a Quick score system. Correlation of 14-3-3ε with patient survival and metastasis was analysed with a Wilcoxon signed rank test, Kaplan-Meier survival curves, and Cox proportional hazard regression. Seventy-one of 114 patients (62.3%) had a significant increase of 14-3-3ε expression in HCC tissues, whereas normal tissues expressed weak or undetectable 14-3-3ε. Elevated 14-3-3ε expression was significantly associated with shortened overall survival and progression-free survival. Furthermore, 14-3-3ε overexpression increased the risk of metastasis 4.6-fold.Overexpression of 14-3-3ε in primary HCC tissues predicts a high risk of extrahepatic metastasis and worse survival, and is a potential therapeutic target.