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Oseltamivir-resistant pandemic influenza a (H1N1) 2009 viruses in Spain.

Research paper by Juan J Ledesma, Diego D Vicente, Francisco F Pozo, Gustavo G Cilla, Sonia Pérez SP Castro, Jonathan Suárez JS Fernández, Mercedes Pérez MP Ruiz, José María JM Navarro, Juan Carlos JC Galán, Mirian M Fernández, Jordi J Reina, Amparo A Larrauri, María Teresa MT Cuevas, Inmaculada I Casas, Pilar Pérez PP Breña, et al.

Indexed on: 20 May '11Published on: 20 May '11Published in: Journal of Clinical Virology



Abstract

Pandemic influenza A (H1N1) 2009 virus appeared in Spain on April 25, 2009 for the first time. This new virus was adamantane-resistant but it was sensitive to neuraminidase (NA) inhibitors oseltamivir and zanamivir.To detect oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses by the Spanish Influenza Surveillance System (SISS) and a possible spread of oseltamivir-resistant viruses in Spain since starting of the pandemic situation.A total of 1229 respiratory samples taken from 413 severe and 766 non-severe patients with confirmed viral detection of pandemic influenza A (H1N1) 2009 viruses from different Spanish regions were analyzed for the specific detection of the H275Y mutation in NA between April 2009 and May 2010.H275Y NA substitution was found in 8 patients infected with pandemic influenza A (H1N1) 2009 viruses collected in November and December 2009 and in January 2010. All oseltamivir-resistant viruses were detected in severe patients (8/413, 1.93%) who previously received treatment with oseltamivir. Six of these patients were immunocompromised.In Spain, the number of oseltamivir-resistant pandemic influenza A (H1N1) 2009 viruses is until now very low. No evidence for any spread of oseltamivir-resistant H1N1 viruses is achieved in our Country.

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